For me the up- and downvote icons are too close together and I always have to pinch zoom to upvote (I don't downvote often). So prefer a bit more spacing between them.
I'd prefer moving them to the same line as "reply", putting them side by side, and changing them to "▲ upvote" and "▼ downvote". Adding the text and putting them side by side makes them easier to hit, and moving them down to the "reply" line frees up valuable space at the left side.
To that newly freed space on the left move the "next" and "prev" links, and if "next" and/or "prev" is not available for a particular comment pad its space so if "next" and/or "prev" is there it is always at the same horizontal position.
This makes it easier to skip forward or back a subtree at a time, because after a given click of "next" or "prev" is executed your mouse or finger will be over the next "next" or "prev".
You can't downvote comments if you have less than 501 karma, and the downvote button doesn't appear on replies to your own comments. Plus, there is no downvote button for stories, just for comments.
An other issue is the link to your profile in order to get back to discussions you were involved in.
On some phone widths, you end up with the profile and "logout" links right above one another and it's even odds you'll have to log back in on all your device because you'll fat-finger the wrong one and there's no confirmation or anything, just straight fuck off.
No idea why that damned logout link can't be moved to the profile, is anyone really in such a hurry to log out they can't just hit two links?