I have literal dozens of these kinds (Node+Express under PM2) of small apps running around everywhere in production (almost 8 years = almost a decade ;). Using SQLite (when you need an actual DB) makes things a lot easier in this regard as well.

I've tried doing some thing in Python (my initial programming love) over the years but I keep going insane because every time I'm forced to read up on the state of ecosystem (choosing versions and package managers and whatnot) and it drives me insane. I just install Node+Express and can get to work immediately (and finish quickly).