I feel like AI/ML and some pre-rigged models could be used to build a web-hosted sitcom. It would take a lot of technical work, and a lot of writing chops to make it watchable, but it could be done.
Look at Space Ghost: Coast to Coast, a show that was made by reusing old animations. If someone writes a script (use humans for now), then the AI/ML can stitch together the animation.
Once there's a corpus of material, start letting the AI determine plot points, and have humans vet and write it. Over time, let the AI take more and more control over the direction of the show, making sure to introduce new characters or events as needed.