So how about a tool that would open an Excel spreadsheet as a sqlite database ? By on-the-fly converting the tabs into tables. Then open this database in your favorite sqlite browser.
Maybe even open several spreadsheet files at once, each file in a separate database.
Neat idea, you could get pretty close to that experience right now by running http://databaseimportscriptor.com, then Alt+Tab-ing into MySQL Workbench.
Problem is, I can't really see a market for it. You're trying to write SQL on your database, so you're a developer, and how much would you really be willing to pay to have the experience streamlined down to a couple of clicks?